Research progress and prospects of exosomal microRNAs in bone malignancies_West China Medical Journal

Authors：

LI Linyang ¹ , ZHANG Yongbo ¹ , ZHANG Yujie ¹ , HUO Lukuan ¹ ,  LIU Yanbin ²

1. School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong 261000, P. R. China;
2. Department of Spine Surgery, Liaocheng People’s Hospital, Beijing Jishuitan Hospital Liaocheng Branch, Liaocheng, Shandong 252000, P. R. China;

Corresponding author：

LIU Yanbin, Email: 15315388294@163.com

Keywords：

Exosomes; microRNA; bone malignancies; drug resistance; therapeutic targets

DOI：

10.7507/1002-0179.202410007

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Bone malignancies exhibit the characteristics of high incidence, poor prognosis, and strong chemoresistance. Exosomal microRNAs can regulate the proliferation of bone malignant cells, improve chemoresistance, influence cell communication and the microenvironment, and have significant potential in the diagnosis and treatment of bone malignancies. Due to their stability, exosomal microRNAs can serve as non-invasive biomarkers for diagnosis and prognosis. However, their widespread application in clinical settings requires standardized research. This review summarizes the progress of exosomal microRNA research in various bone malignancies including osteosarcoma, chondrosarcoma, Ewing sarcoma, and fibrosarcoma, to provide new theoretical foundations and perspectives for the field.

Citation： LI Linyang, ZHANG Yongbo, ZHANG Yujie, HUO Lukuan, LIU Yanbin. Research progress and prospects of exosomal microRNAs in bone malignancies. West China Medical Journal, 2024, 39(12): 1978-1982. doi: 10.7507/1002-0179.202410007 Copy

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2. Sato-Kuwabara Y, Melo SA, Soares FA, et al. The fusion of two worlds: non-coding RNAs and extracellular vesicles--diagnostic and therapeutic implications (Review). Int J Oncol, 2015, 46(1): 17-27.
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Research progress and prospects of exosomal microRNAs in bone malignancies

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